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PGD

Egg Donation New JerseyPreimplantation Genetic Diagnosis (PGD) is a relatively new procedure, used in conjunction with in vitro fertilization, which helps increase the likelihood of genetically normal embryos to be selected for transfer to the uterus. PGD involves the microsurgical removal and biopsy of one blastomere (cell) from a six to eight cell embryo. The genetic diagnosis of the blastomere can be accomplished by using either PCR (polymerase chain reaction) or FISH (fluorescence in situ hybridization), depending on the indication for PGD. By prescreening a representative cell from each Day 3 embryo, the healthiest embryos with the greatest potential for implantation can be identified.

Artificial InseminationPreimplantation genetic diagnosis has been shown to be helpful for specific groups of patients. Women with recurrent miscarriage due to chromosome issues have been shown to have higher implantation rates and reduced spontaneous abortion rates when PGD is used in conjunction with IVF. In addition, carriers of single gene disorders (e.g. cystic fibrosis, thalassemia) benefit from prescreening of their embryos before they are transferred. PGD for gender selection in sex-linked disorders is also routinely utilized to improve chances for a successful outcome (i.e. having an unaffected pregnancy). By identifying the sex of the embryo, sex-linked disorders such as hemophilia can be avoided. The benefit of PGD is less clear in other groups of patients, including those with unexplained infertility, advanced maternal age, or repeat IVF failure.

Fertility Center New JerseyThe biopsy of the embryo and subsequent molecular analysis of the blastomere are both technically demanding and complex procedures that require highly trained laboratory personnel. Genetic results are usually reported within 24 hours of the biopsy, allowing for the subsequent transfer of unaffected embryos