Categories for IUI

Clomiphene (Clomid) Better than Letrozole for Treating Women with Unexplained Infertility

Posted on August 10, 2015  by   Leave your thoughts

ClomidCouples with unexplained infertility — those in whom no significant problems are found after a fertility investigation by their doctor — struggle to find the best treatment.


Until now, fertility experts have generally agreed that the first line of therapy for such couples is a combination of clomiphene (Clomid) and intrauterine insemination, or IUI. Other experts feel that letrozole should be used instead of clomiphene since it may produce a lower risk of twin pregnancy.


Clomid vs. Letrozole trial

Researchers from the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) trial looked at this question and presented their study results at a recent annual meeting of the American Society of Reproductive Medicine (ASRM). This prospective, randomized, multicenter clinical trial involved 900 women aged 18 to 40 years. The study concluded that:


  • Birth rates were lower with letrozole than with clomiphene
  • More multiple births occurred with letrozole
  • No difference was found in the rates of infants with birth defects or other fetal or newborn complications when comparing clomiphene to letrozole

Although both treatments were found to be safe, the higher birth rate with clomiphene should keep that as a top choice for fertility specialists treating patients with unexplained infertility.


To learn more about IUI, read a previous blog post here: Will IUI Work for Me?


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Will IUI Work for Me?

Posted on February 26, 2015  by   1 Comment

Many of our patients come in expecting to have to go through the cost and experience of in vitro fertilization (IVF), but there is another treatment available for most that is less invasive and less costly, and can still result in pregnancy – IUI.   Since so many people hear infertility and think IVF, there... Continue Reading

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Women Ages 38-43 Have 3x Higher Pregnancy Rate With IVF Vs IUI

Posted on January 4, 2012  by  

The ideal and most effective means to treat unexplained infertility in older women is uncertain. Most fertility specialists proceed in a step‐wise fashion from simpler to more complex (an expensive) treatments to see what works for the patient. Insurance companies often require this step‐wise approach since it limits expenses. The step‐wise approach can sometimes be... Continue Reading

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